Promethazine is metabolized through the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing from the urine.
Small children Postmarketing circumstances of respiratory depression, which includes fatalities, are claimed with usage of promethazine in pediatric sufferers. Concomitant administration with other respiratory depressants may raise the possibility of respiratory melancholy.
Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. Keep an eye on sufferers for indications of diminished diuresis and/or results on blood pressure and improve the dosage of your diuretic as wanted.
Dosage of codeine Shouldn't be Greater if cough fails to reply; an unresponsive cough must be reevaluated in 5 days or sooner for attainable underlying pathology, which include foreign body or decrease respiratory tract ailment.
g., All those with evidence of greater intracranial strain or brain tumors), Promethazine HCl and Codeine Phosphate Oral Solution might cut down respiratory push, plus the resultant CO2 retention can additional enhance intracranial pressure. Additionally, opioids make adverse reactions which will obscure the scientific program of people with head accidents.
Pregnancy Exams: Diagnostic pregnancy assessments according to immunological reactions between HCG and anti-HCG may possibly lead to Fake-destructive or Wrong-optimistic interpretations.
Although the threat of habit in almost any unique is not known, it could take place in patients appropriately prescribed Promethazine HCl and Codeine Phosphate Oral Alternative. Dependancy can occur at encouraged dosages and If your drug is misused or abused. Threats are improved in people with a personal or household background of substance abuse (which include drug or Alcoholic beverages abuse or habit) or mental sickness (e.g., big depression).
A pharmacist can advocate an appropriate measuring unit and can provide Recommendations for measuring the proper dose.
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This is not a Promethazine codeine syrup complete listing of probable Unintended effects. For those who discover other Uncomfortable side effects not outlined higher than, Get hold of your medical professional or pharmacist.
Narcotic analgesics lead to histamine release, which seems for being answerable for wheals or urticaria often witnessed at the site of injection on parenteral administration.
Postmarketing instances of respiratory melancholy, including fatalities are already claimed with use of promethazine in pediatric people.
Narcotic analgesics or cough suppressants, like codeine, really should not be Employed in asthmatic patients (see CONTRAINDICATIONS). Nor should really they be used in acute febrile illness affiliated with successful cough or in Serious respiratory illness the place interference with ability to distinct the tracheobronchial tree of secretions would have a deleterious effect on the individual's respiratory perform.
Concomitant administration of promethazine products and solutions with other respiratory depressants has an Affiliation with respiratory melancholy, and from time to time Demise, in pediatric sufferers.